TB-500

Also known as: Thymosin Beta-4 fragment, TB4-Frag

TB-500 is a synthetic fragment (residues 17–23) of the naturally occurring 43-amino-acid protein thymosin beta-4.

Research context

TB-500 is a synthetic fragment (residues 17–23) of the naturally occurring 43-amino-acid protein thymosin beta-4. In preclinical research it is studied for its role in actin sequestration, cell migration, and vascular formation. Investigators use TB-500 in wound-healing assays, cardiac ischemia-reperfusion models, and equine soft-tissue studies. The truncated peptide is significantly smaller than full-length thymosin beta-4 and is easier to synthesize at research-grade purity. No human therapeutic indications are approved; the peptide is prohibited by the World Anti-Doping Agency for use in athletes and is supplied here exclusively as a laboratory reference compound.

Storage & stability

Store lyophilized at -20°C. Reconstituted material at 2–8°C, use within 4 weeks.

Purity & testing standards

Each batch of TB-500 is analyzed by an independent third-party laboratory. Standard release testing includes reverse-phase HPLC at 220 nm (purity target HPLC ≥99%), electrospray mass spectrometry (identity confirmation), and endotoxin screening. Batch numbers on each vial resolve to a downloadable COA on this site.

Recent COAs

Batch	Lab	HPLC	Date
RUO-TB-500-2409A	Janoshik Analytical	99.4%	2026-06-06

FAQ

What is TB-500 derived from?+

TB-500 is a synthetic 7-residue fragment corresponding to the active region of the endogenous protein thymosin beta-4.